Malaria is a serious parasitic disease characterized by fever, chills, and anemia and is caused by a parasite that is transmitted from one human to another by the bite of infected Anopheles mosquitoes. There four kinds of malaria that can infect humans: Plasmodium falcioarum, P.vivax, P.ovale, and P.malariae. In humans, the parasites migrate to the liver where they mature and release another form, the merozoites.

   The One Step Malaria pf(HRP II) / PANLDH Antigen Detection Test Device (Whole Blood) contains a membrane strip, which is pre-coated with two monoclonal antibodies as two separate lines across a test strip. One monoclonal antibodies (test line 1) is specific to the P.falciparum histidine rich protein-2 (Pf  HRP-2) and another monoclonal antibodies (test lines 2) is specific to the lactate dehydrogenase of Plasmodium species (P.falciparum, vivax, malariae, ovale). Conjugate pad is pre-coated with monoclonal antibodies conjugated to colloidal gold, which are specific to P.falcparum histidine rich protein-2 (Pf HRP-2) and pan specific to the lactate dehydrogenase of Plasmodium species.